Psychosis

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Psychosis (from the Greek ψυχή "psyche", for mind/soul, and -ωσις "-osis", for abnormal condition) means abnormal condition of the mind, and is a generic psychiatric term for a mental state often described as involving a "loss of contact with reality". People suffering from psychosis are described as psychotic. Psychosis is given to the more severe forms of psychiatric disorder, during which hallucinations and delusions and impaired insight may occur.[1] Some professionals say that the term psychosis is not sufficient as some illnesses grouped under the term "psychosis" have nothing in common (Gelder, Mayou & Geddes 2005)

People experiencing psychosis may report hallucinations or delusional beliefs, and may exhibit personality changes and thought disorder. Depending on its severity, this may be accompanied by unusual or bizarre behavior, as well as difficulty with social interaction and impairment in carrying out the daily life activities.

A wide variety of central nervous system diseases, from both external poisons and internal physiologic illness, can produce symptoms of psychosis.

Signs and symptoms

People with psychosis may have one or more of the following: hallucinations, delusions, or a thought disorder, as described below.

Hallucinations

A hallucination is defined as sensory perception in the absence of external stimuli. Hallucinations are different from illusions, or perceptual distortions, which are the misperception of external stimuli.[2] Hallucinations may occur in any of the five senses and take on almost any form, which may include simple sensations (such as lights, colors, tastes, and smells) to more meaningful experiences such as seeing and interacting with fully formed animals and people, hearing voices, and having complex tactile sensations.

Auditory hallucinations, particularly experiences of hearing voices, are a common and often prominent feature of psychosis. Hallucinated voices may talk about, or to, the person, and may involve several speakers with distinct personas. Auditory hallucinations tend to be particularly distressing when they are derogatory, commanding or preoccupying. However, the experience of hearing voices need not always be a negative one. One research study has shown that the majority of people who hear voices are not in need of psychiatric help.[3] The Hearing Voices Movement has subsequently been created to support voice hearers, regardless of whether they are considered to have a mental illness or not.

Delusions

Psychosis may involve delusional beliefs, some of which are paranoid in nature. Karl Jaspers has classified psychotic delusions into primary and secondary types. Primary delusions are defined as arising suddenly and not being comprehensible in terms of normal mental processes, whereas secondary delusions may be understood as being influenced by the person's background or current situation (e.g., ethnic or sexual orientation, religious beliefs, superstitious belief).[4]

Thought disorder

Thought disorder describes an underlying disturbance to conscious thought and is classified largely by its effects on speech and writing. Affected persons show loosening of associations, that is, a disconnection and disorganization of the semantic content of speech and writing. In the severe form speech becomes incomprehensible and it is known as "word-salad".

Causes

Causes of symptoms of mental illness were customarily classified as "organic" or "functional". Organic conditions are primarily medical or pathophysiological, whereas, functional conditions are primarily psychiatric or psychological. The DSM-IV-TR no longer classifies psychotic disorders as functional or organic. Rather it lists traditional psychotic illnesses, psychosis due to General Medical conditions, and Substance induced psychosis.

Psychiatric

Functional causes of psychosis include the following:

A psychotic episode can be significantly affected by mood. For example, people experiencing a psychotic episode in the context of depression may experience persecutory or self-blaming delusions or hallucinations, while people experiencing a psychotic episode in the context of mania may form grandiose delusions.

Stress is known to contribute to and trigger psychotic states. A history of psychologically traumatic events, and the recent experience of a stressful event, can both contribute to the development of psychosis. Short-lived psychosis triggered by stress is known as brief reactive psychosis, and patients may spontaneously recover normal functioning within two weeks.[7] In some rare cases, individuals may remain in a state of full-blown psychosis for many years, or perhaps have attenuated psychotic symptoms (such as low intensity hallucinations) present at most times.

Sleep deprivation has been linked to psychosis.[8][9][10] However, this is not a risk for most people, who merely experience hypnagogic or hypnopompic hallucinations, i.e. unusual sensory experiences or thoughts that appear during waking or drifting off to sleep. These are normal sleep phenomena and are not considered signs of psychosis.[11]

Vitamin B12 deficiency can also cause symptoms of mania and psychosis.[12][13]

Vitamin D overdose can cause altered thinking and psychosis.[14]

Genetics may also have a role in psychosis. The Genain quadruplets were identical quadruplets who were all diagnosed with schizophrenia. Although having grown up in the same environment means it could be any other common factor, like for example having the same parents with the same behavior towards them.

General medical

Psychosis arising from "organic" (non-psychological) conditions is sometimes known as secondary psychosis. It can be associated with the following pathologies:

Psychosis can even be caused by apparently innocuous ailments such as flu[49][50] or mumps.[51]

Psychoactive drugs

Various psychoactive substances (both legal and illegal) have been implicated in causing, exacerbating, and/or precipitating psychotic states and/or disorders in users. Frequent use of cannabis doubles both the risk of psychosis and schizophrenia[52] Older studies indicate that certain strains containing large proportions of THC and low proportions of CBD,[53][54] merely lowers the threshold for psychosis, and thus helps to trigger full-blown psychosis in some people.[55] On the other hand, cannabis use has increased dramatically over the past few decades but declined in the last decade, whereas the rate of psychosis has not increased. This suggests that a direct causal link is unlikely for all users.[56]

Prescription medication

Some medications such as bromocriptine and phenylpropanolamine may also cause or worsen psychotic symptoms.[57][58][59]

Pathophysiology

The first brain image of an individual with psychosis was completed as far back as 1935 using a technique called pneumoencephalography[60] (a painful and now obsolete procedure where cerebrospinal fluid is drained from around the brain and replaced with air to allow the structure of the brain to show up more clearly on an X-ray picture).

The purpose of the brain is to collect information from the body (pain, hunger, etc.), and from the outside world, interpret it to a coherent world view, and produce a meaningful response. The information from the senses enter the brain in the primary sensory areas. They process the information and send it to the secondary areas where the information is interpreted. Spontaneous activity in the primary sensory areas may produce hallucinations which are misinterpreted by the secondary areas as information from the real world.

For example, a PET or fMRI scan of a person who claims to be hearing voices may show activation in the primary auditory cortex, or parts of the brain involved in the perception and understanding of speech.[61]

Tertiary brain cortex collects the interpretations from the secondary cortexes and creates a coherent world view of it. A study investigating structural changes in the brains of people with psychosis showed there was significant grey matter reduction in the right medial temporal, lateral temporal, and inferior frontal gyrus, and in the cingulate cortex bilaterally of people before and after they became psychotic.[62] Findings such as these have led to debate about whether psychosis itself causes excitotoxic brain damage and whether potentially damaging changes to the brain are related to the length of psychotic episode. Recent research has suggested that this is not the case[63] although further investigation is still ongoing.

Studies with sensory deprivation have shown that the brain is dependent on signals from the outer world to function properly. If the spontaneous activity in the brain is not counterbalanced with information from the senses, loss from reality and psychosis may occur after some hours. A similar phenomenon is paranoia in the elderly when poor eyesight, hearing and memory causes the person to be abnormally suspicious of the environment.

On the other hand, loss from reality may also occur if the spontaneous cortical activity is increased so that it is no longer counterbalanced with information from the senses. The 5-HT2A receptor seems to be important for this, since drugs which activate them produce hallucinations.

However, the main feature of psychosis is not hallucinations, but the inability to distinguish between internal and external stimuli. Close relatives to psychotic patients may hear voices, but since they are aware that they are unreal they can ignore them, so that the hallucinations do not affect their reality perception. Hence they are not considered to be psychotic.

Psychosis has been traditionally linked to the neurotransmitter dopamine. In particular, the dopamine hypothesis of psychosis has been influential and states that psychosis results from an overactivity of dopamine function in the brain, particularly in the mesolimbic pathway. The two major sources of evidence given to support this theory are that dopamine receptor D2 blocking drugs (i.e., antipsychotics) tend to reduce the intensity of psychotic symptoms, and that drugs which boost dopamine activity (such as amphetamines and cocaine) can trigger psychosis in some people (see amphetamine psychosis).[64] However, increasing evidence in recent times has pointed to a possible dysfunction of the excitory neurotransmitter glutamate, in particular, with the activity of the NMDA receptor. This theory is reinforced by the fact that dissociative NMDA receptor antagonists such as ketamine, PCP and dextromethorphan/detrorphan (at large overdoses) induce a psychotic state more readily than dopinergic stimulants, even at "normal" recreational doses. The symptoms of dissociative intoxication are also considered to mirror the symptoms of schizophrenia, including negative psychotic symptoms, more closely than amphetamine psychosis. Dissociative induced psychosis happens on a more reliable and predictable basis than amphetamine psychosis, which usually only occurs in cases of overdose, prolonged use or with sleep deprivation, which can independently produce psychosis. New antipsychotic drugs which act on glutamate and its receptors are currently undergoing clinical trials.

The connection between dopamine and psychosis is generally believed to be complex. While dopamine receptor D2 suppresses adenylate cyclase activity, the D1 receptor increases it. If D2-blocking drugs are administered the blocked dopamine spills over to the D1 receptors. The increased adenylate cyclase activity affects genetic expression in the nerve cell, a process which takes time. Hence antipsychotic drugs take a week or two to reduce the symptoms of psychosis. Moreover, newer and equally effective antipsychotic drugs actually block slightly less dopamine in the brain than older drugs whilst also blocking 5-HT2A receptors, suggesting the 'dopamine hypothesis' may be oversimplified.[65] Soyka and colleagues found no evidence of dopaminergic dysfunction in people with alcohol-induced psychosis[66] and Zoldan et al. reported moderately successful use of ondansetron, a 5-HT3 receptor antagonist, in the treatment of levodopa psychosis in Parkinson's disease patients.[67]

Psychiatrist David Healy has criticised pharmaceutical companies for promoting simplified biological theories of mental illness that seem to imply the primacy of pharmaceutical treatments while ignoring social and developmental factors which are known to be important influences in the aetiology of psychosis.[68]

Some theories regard many psychotic symptoms to be a problem with the perception of ownership of internally generated thoughts and experiences.[69] For example, the experience of hearing voices may arise from internally generated speech that is mislabeled by the psychotic person as coming from an external source.

One clear finding is that persons with bipolar disorder seem to have increased activity of the left hemisphere compared to the right hemisphere of the brain, while persons with schizophrenia have increased activity in the right hemisphere.[70]

Increased level of right hemisphere activation has also been found in people who have high levels of paranormal beliefs[71] and in people who report mystical experiences.[72] It also seems to be the case that people who are more creative are also more likely to show a similar pattern of brain activation.[73] Some researchers have been quick to point out that this in no way suggests that paranormal, mystical or creative experiences are in any way by themselves a symptom of mental illness, as it is still not clear what makes some such experiences beneficial and others distressing.

Diagnosis

The Brief Psychiatric Rating Scale (BPRS) [74] assesses the level of 18 symptom constructs of psychosis such as hostility, suspicion, hallucination, and grandiosity. It is based on the clinician's interview with the patient and observations of the patient's behavior over the previous 2–3 days. The patient's family can also provide the behavior report. During the initial assessment and the follow-up, both positive and negative symptoms of psychosis can be assessed using the 30 item Positive and Negative Symptom Scale (PANSS).[75]

Treatment

The treatment of psychosis depends on the cause or diagnosis or diagnoses (such as schizophrenia, bipolar disorder and/ or substance intoxication). The first line treatment for many psychotic disorders is antipsychotic medication (oral or intramuscular injection), and sometimes hospitalization is needed. There is growing evidence that cognitive behavior therapy[76] and family therapy[77] can be effective in managing psychotic symptoms. When other treatments for psychosis are ineffective, electroconvulsive therapy (ECT) (aka shock treatment) is sometimes applied to relieve the underlying symptoms of psychosis due to depression. There is also increasing research suggesting that animal-assisted therapy can contribute to the improvement in general well-being of people with schizophrenia.[78]

Early intervention

Early intervention in psychosis is a relatively new concept based on the observation that identifying and treating someone in the early stages of a psychosis can significantly improve their longer term outcome.[79] This approach advocates the use of an intensive multi-disciplinary approach during what is known as the critical period, where intervention is the most effective, and prevents the long term morbidity associated with chronic psychotic illness.

Newer research into the effectiveness of cognitive behavioural therapy during the early pre-cursory stages of psychosis (also known as the "prodrome" or "at risk mental state") suggests that such input can prevent or delay the onset of psychosis.[80]

One of the international paradigms aimed at researching the prodrome is the North American Prodrome Longitudinal Study (NAPLS). The study is concerned with brain development, hormones, and neuropsychological functions that may play a role in risk for and prevention of mental illness in young adulthood. Specifically, the goal is to determine the neurobiological indicators present in prodromal patients that may contribute to the onset of severe mental illness as compared with those of control individuals.

History

The word psychosis was first used by Ernst von Feuchtersleben in 1845[81] as an alternative to insanity and mania and stems from the Greek ψύχωσις (psychosis), "a giving soul or life to, animating, quickening" and that from ψυχή (psyche), "soul" and the suffix -ωσις (-osis), in this case "abnormal condition".[82][83] The word was used to distinguish disorders which were thought to be disorders of the mind, as opposed to "neurosis", which was thought to stem from a disorder of the nervous system.[84] The psychoses thus became the modern equivalent of the old notion of madness, and hence there was much debate on whether there was only one (unitary) or many forms of the new disease.[85]

The division of the major psychoses into manic depressive illness (now called bipolar disorder) and dementia praecox (now called schizophrenia) was made by Emil Kraepelin, who attempted to create a synthesis of the various mental disorders identified by 19th century psychiatrists, by grouping diseases together based on classification of common symptoms. Kraepelin used the term 'manic depressive insanity' to describe the whole spectrum of mood disorders, in a far wider sense than it is usually used today. In Kraepelin's classification this would include 'unipolar' clinical depression, as well as bipolar disorder and other mood disorders such as cyclothymia. These are characterised by problems with mood control and the psychotic episodes appear associated with disturbances in mood, and patients will often have periods of normal functioning between psychotic episodes even without medication. Schizophrenia is characterized by psychotic episodes which appear to be unrelated to disturbances in mood, and most non-medicated patients will show signs of disturbance between psychotic episodes.

During the 1960s and 1970s, psychosis was of particular interest to counterculture critics of mainstream psychiatric practice, who argued that it may simply be another way of constructing reality and is not necessarily a sign of illness. For example, R. D. Laing argued that psychosis is a symbolic way of expressing concerns in situations where such views may be unwelcome or uncomfortable to the recipients. He went on to say that psychosis could be also seen as a transcendental experience with healing and spiritual aspects. Arthur J. Deikman suggested use of the term "mystical psychosis" to characterize first-person accounts of psychotic experiences that are similar to reports of mystical experiences. Thomas Szasz focused on the social implications of labeling people as psychotic, a label he argues unjustly medicalises different views of reality so such unorthodox people can be controlled by society. Psychoanalysis has a detailed account of psychosis which differs markedly from that of psychiatry. Freud and Lacan outlined their perspective on the structure of psychosis in a number of works.

Since the 1970s, the introduction of a recovery approach to mental health, which has been driven mainly by people who have experienced psychosis (or whatever name is used to describe their experiences), has led to a greater awareness that mental illness is not a lifelong disability, and that there is an expectation that recovery is possible, and probable with effective support.

See also

References

  1. ↑ Gelder, Michael (2005). "Psychiatry", P. 12. Oxford University Press Inc., New York. ISBN 9780198528630.
  2. ↑ Harper, Douglas (November 2001). "hallucinate". Online Etymology Dictionary. http://www.etymonline.com/index.php?search=hallucinate&searchmode=none. Retrieved October 15, 2006. 
  3. ↑ Honig A, Romme MA, Ensink BJ, Escher SD, Pennings MH, deVries MW (October 1998). "Auditory hallucinations: a comparison between patients and nonpatients". J. Nerv. Ment. Dis. 186 (10): 646–51. doi:10.1097/00005053-199810000-00009. PMID 9788642. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0022-3018&volume=186&issue=10&spage=646. 
  4. ↑ Jaspers, Karl (1997-11-27) [1963]. Allgemeine Psychopathologie (General Psychopathology). Translated by J. Hoenig & M.W. Hamilton from German (Reprint ed.). Baltimore, Maryland: Johns Hopkins University Press. ISBN 0-8018-5775-9. 
  5. ↑ Leweke FM, Koethe D (June 2008). "Cannabis and psychiatric disorders: it is not only addiction". Addict Biol 13 (2): 264–75. doi:10.1111/j.1369-1600.2008.00106.x. PMID 18482435. 
  6. ↑ Tien AY, Anthony JC (August 1990). "Epidemiological analysis of alcohol and drug use as risk factors for psychotic experiences". J. Nerv. Ment. Dis. 178 (8): 473–80. doi:10.1097/00005053-199017880-00001. PMID 2380692. 
  7. ↑ Jauch, D. A.; William T. Carpenter, Jr. (February 1988). "Reactive psychosis. I. Does the pre-DSM-III concept define a third psychosis?". Journal of Nervous and Mental Disease 176 (2): 72–81. doi:10.1097/00005053-198802000-00002. PMID 3276813. 
  8. ↑ Sharma, Verinder; Dwight Mazmanian (April 2003). "Sleep loss and postpartum psychosis". Bipolar Disorders 5 (2): 98–105. doi:10.1034/j.1399-5618.2003.00015.x. PMID 12680898. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1398-5647&date=2003&volume=5&issue=2&spage=98. Retrieved 2006-09-27. 
  9. ↑ Chan-Ob, T.; V. Boonyanaruthee (September 1999). "Meditation in association with psychosis". Journal of the Medical Association of Thailand 82 (9): 925–930. PMID 10561951. 
  10. ↑ Devillieres, P.; M. Opitz, P. Clervoy, and J. Stephany (May–June 1996). "[Delusion and sleep deprivation]". L'Encéphale 22 (3): 229–31. 
  11. ↑ Ohayon, M. M.; R. G. Priest, M. Caulet, and C. Guilleminault (October 1996). "Hypnagogic and hypnopompic hallucinations: pathological phenomena?". British Journal of Psychiatry 169 (4): 459–67. doi:10.1192/bjp.169.4.459. PMID 8894197. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8894197.ui. Retrieved 2006-10-21. 
  12. ↑ Sethi NK, Robilotti E, Sadan Y (2005). "Neurological Manifestations Of Vitamin B-12 Deficiency". The Internet Journal of Nutrition and Wellness 2 (1). 
  13. ↑ Masalha R, Chudakov B, Muhamad M, Rudoy I, Volkov I, Wirguin I (September 2001). "Cobalamin-responsive psychosis as the sole manifestation of vitamin B12 deficiency". Isr. Med. Assoc. J. 3 (9): 701–3. PMID 11574992. http://www.ima.org.il/imaj/dynamic/web/ArtFromPubmed.asp?year=2001&month=09&page=701. 
  14. ↑ The Dana Guide to Brain Health
  15. ↑ Lisanby, S. H.; C. Kohler, C. L. Swanson, and R. E. Gur (January 1998). "Psychosis Secondary to Brain Tumor". Seminars in clinical neuropsychiatry 3 (1): 12–22. PMID 10085187. 
  16. ↑ McKeith, Ian G. (February 2002). "Dementia with Lewy bodies". British Journal of Psychiatry 180: 144–7. doi:10.1192/bjp.180.2.144. PMID 11823325. 
  17. ↑ Template:Es icon Rodriguez Gomez, Diego; Elvira Gonzalez Vazquez and Óscar Perez Carral (August 16–31, 2005). "Psicosis aguda como inicio de esclerosis multiple / Acute psychosis as the presenting symptom of multiple sclerosis / Psicose aguda como inicio de esclerose multipla". Revista de Neurología 41 (4): 255–6. PMID 16075405. http://www.revneurol.com/LinkOut/formMedLine.asp?Refer=2005320&Revista=RevNeurol. Retrieved 2006-09-27. 
  18. ↑ Bona, Joseph R.; Sondralyn M. Fackler, Morris J. Fendley and Charles B. Nemeroff (1 August 1998). "Neurosarcoidosis as a Cause of Refractory Psychosis: A Complicated Case Report". American Journal of Psychiatry 155 (8): 1106–8. PMID 9699702. http://www.ajp.psychiatryonline.org/cgi/content/full/155/8/1106. Retrieved 2006-09-29. 
  19. ↑ Fallon BA, Nields JA (November 1994). "Lyme disease: a neuropsychiatric illness". Am J Psychiatry 151 (11): 1571–83. PMID 7943444. http://ajp.psychiatryonline.org/cgi/pmidlookup?view=long&pmid=7943444. 
  20. ↑ Hess A, Buchmann J, Zettl UK, et al. (March 1999). "Borrelia burgdorferi central nervous system infection presenting as an organic schizophrenialike disorder". Biol. Psychiatry 45 (6): 795. doi:10.1016/S0006-3223(98)00277-7. PMID 10188012. http://linkinghub.elsevier.com/retrieve/pii/S0006322398002777. 
  21. ↑ van den Bergen HA, Smith JP, van der Zwan A (October 1993). "[Lyme psychosis]" (in Dutch; Flemish). Ned Tijdschr Geneeskd 137 (41): 2098–100. PMID 8413733. 
  22. ↑ Kararizou E, Mitsonis C, Dimopoulos N, Gkiatas K, Markou I, Kalfakis N (May-Jun 2006). "Psychosis or simply a new manifestation of neurosyphilis?". J. Int. Med. Res. 34 (3): 335–7. PMID 16866029. http://openurl.ingenta.com/content/nlm?genre=article&issn=0300-0605&volume=34&issue=3&spage=335&aulast=Kararizou. 
  23. ↑ Brooke D, Jamie P, Slack R, Sulaiman M, Tyrer P (October 1987). "Neurosyphilis—a treatable psychosis". Br J Psychiatry 151: 556. doi:10.1192/bjp.151.4.556. PMID 3447677. 
  24. ↑ Lesser JM, Hughes S (December 2006). "Psychosis-related disturbances. Psychosis, agitation, and disinhibition in Alzheimer's disease: definitions and treatment options". Geriatrics 61 (12): 14–20. PMID 17184138. 
  25. ↑ Wedekind S (June 2005). "[Depressive syndrome, psychoses, dementia: frequent manifestations in Parkinson disease]" (in German). MMW Fortschr Med 147 (22): 11. PMID 15977623. 
  26. ↑ Nasky KM, Knittel DR, Manos GH (August 2008). "Psychosis associated with anti-N-methyl-D-aspartate receptor antibodies". CNS Spectr 13 (8): 699–703. http://www.cnsspectrums.com/aspx/articledetail.aspx?articleid=1677. 
  27. ↑ Rossman, Phillip L.; Robert M. Vock (September 1956). "Postpartum Tetany and Psychosis Due to Hypocalcemia". California Medicine 85 (3): 190–3. PMC Template:=pmcentrez&artidTemplate:=1531921 1531921. PMID 13356186. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1531921. Retrieved 2006-10-16. 
  28. ↑ Jana, D. K.; L. Romano-Jana (October 1973). "Hypernatremic psychosis in the elderly: case reports". Journal of the American Geriatrics Society 21 (10): 473–7. PMID 4729012. 
  29. ↑ Haensch, C. A.; G. Hennen and J. Jorg (April 1996). "[Reversible exogenous psychosis in thiazide-induced hyponatremia of 97 mmol/l]". Der Nervenarzt 67 (4): 319–22. PMID 8684511. 
  30. ↑ Hafez, H.; J. S. Strauss, M. D. Aronson, and C. Holt (June 1984). "Hypokalemia-induced psychosis in a chronic schizophrenic patient". Journal of Clinical Psychiatry 45 (6): 277–9. PMID 6725222. 
  31. ↑ Konstantakos, Anastasios K.; Enrique Grisoni (May 25, 2006). "Hypomagnesemia". eMedicine. WebMD. http://www.emedicine.com/ped/topic1122.htm. Retrieved October 16, 2006. 
  32. ↑ Velasco, P. Joel; Manoochehr Manshadi, Kevin Breen, and Steven Lippmann (1 December 1999). "Psychiatric Aspects of Parathyroid Disease". Psychosomatics 40 (6): 486–90. PMID 10581976. http://psy.psychiatryonline.org/cgi/content/full/40/6/486. Retrieved 2006-10-17. 
  33. ↑ Rosenthal, M.; I. Gil and B. Habot (1997). "Primary hyperparathyroidism: neuropsychiatric manifestations and case report". Israel Journal of Psychiatry and Related Sciences 34 (2): 122–125. PMID 9231574. 
  34. ↑ Nanji, A. A. (November 1984). "The psychiatric aspect of hypophosphatemia". Canadian Journal of Psychiatry 29 (7): 599–600. PMID 6391648. 
  35. ↑ Padder, Tanveer; Aparna Udyawar, Nouman Azhar, and Kamil Jaghab (December 2005). "Acute Hypoglycemia Presenting as Acute Psychosis". Psychiatry online. http://www.priory.com/psych/hypg.htm. Retrieved 2006-09-27. 
  36. ↑ Robert, M.; R. Sunitha, and N. K. Thulaseedharan (1 March 2006). "Neuropsychiatric manifestations systemic lupus erythematosus: A study from South India". Neurology India 54 (1): 75–7. doi:10.4103/0028-3886.24713. PMID 16679649. http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2006;volume=54;issue=1;spage=75;epage=77;aulast=Robert. Retrieved 2006-09-29. 
  37. ↑ Evans, Dwight L.; Karen I. Mason, Jane Leserman, Russell Bauer And John Petitto (2002-02-01). "Chapter 90: Neuropsychiatric Manifestations of HIV-1 Infection and AIDS". In Kenneth L Davis, Dennis Charney, Joseph T Coyle, Charles Nemeroff. Neuropsychopharmacology: The Fifth Generation of Progress (5th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 1281–1301. ISBN 0-7817-2837-1. http://www.acnp.org/g4/GN401000149/CH146.html. Retrieved 2006-10-16. 
  38. ↑ Lowinger, Paul (July 1959). "Leprosy And Psychosis". American Journal of Psychiatry 116 (1): 32–37. doi:10.1176/appi.ajp.116.1.32 (inactive 2008-06-25). PMID 13661445. http://ajp.psychiatryonline.org/cgi/content/abstract/116/1/32. Retrieved 2006-10-17. 
  39. ↑ Ponomareff, G. L. (June 1965). "Phenomenology Of Delusions In A Case Of Leprosy" (PDF). American Journal of Psychiatry 121 (12): 1211. PMID 14286061. http://ajp.psychiatryonline.org/cgi/reprint/121/12/1211. Retrieved 2006-10-17. 
  40. ↑ Tilluckdharry, C. C.; D. D. Chaddee, R. Doon, and J. Nehall (March 1996). "A case of vivax malaria presenting with psychosis". West Indian Medical Journal 45 (1): 39–40. PMID 8693739. 
  41. ↑ Denier C, Orgibet A, Roffi F, Jouvent E, Buhl C, Niel F, Boespflug-Tanguy O, Said G, Ducreux D (2007). "Adult-onset vanishing white matter leukoencephalopathy presenting as psychosis". Neurology 68 (18): 1538–9. doi:10.1212/01.wnl.0000260701.76868.44. PMID 17470759. 
  42. ↑ Hermle L, Becker FW, Egan PJ, Kolb G, Wesiack B, Spitzer M (1997). "[Metachromatic leukodystrophy simulating schizophrenia-like psychosis]" (in German). Der Nervenarzt 68 (9): 754–8. PMID 9411279. 
  43. ↑ Black DN, Taber KH, Hurley RA (2003). "Metachromatic leukodystrophy: a model for the study of psychosis". The Journal of neuropsychiatry and clinical neurosciences 15 (3): 289–93. PMID 12928504. free full text
  44. ↑ Kumperscak HG, Paschke E, Gradisnik P, Vidmar J, Bradac SU (2005). "Adult metachromatic leukodystrophy: disorganized schizophrenia-like symptoms and postpartum depression in 2 sisters". Journal of psychiatry & neuroscience : JPN 30 (1): 33–6. PMC Template:=pmcentrez&artidTemplate:=543838 543838. PMID 15644995. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=543838. 
  45. ↑ Müller N, Gizycki-Nienhaus B, Botschev C, Meurer M (August 1993). "Cerebral involvement of scleroderma presenting as schizophrenia-like psychosis". Schizophr. Res. 10 (2): 179–81. doi:10.1016/0920-9964(93)90054-M. PMID 8398950. 
  46. ↑ Wilcox RA, To T, Koukourou A, Frasca J (November 2008). "Hashimoto's encephalopathy masquerading as acute psychosis". J Clin Neurosci 15 (11): 1301–4. doi:10.1016/j.jocn.2006.10.019. PMID 18313925. http://linkinghub.elsevier.com/retrieve/pii/S0967-5868(07)00043-4. 
  47. ↑ Gómez-Bernal GJ, Reboreda A, Romero F, Bernal MM, Gómez F (2007). "A Case of Hashimoto's Encephalopathy Manifesting as Psychosis". Prim Care Companion J Clin Psychiatry 9 (4): 318–9. doi:10.4088/PCC.v09n0411f. PMC Template:=pmcentrez&artidTemplate:=2018852 2018852. PMID 17934563. 
  48. ↑ Ray M, Kothur K, Padhy SK, Saran P (May 2007). "Hashimoto's encephalopathy in an adolescent boy". Indian J Pediatr 74 (5): 492–4. doi:10.1007/s12098-007-0084-0. PMID 17526963. 
  49. ↑ Steinberg, D.; S. R. Hirsch, S. D. Marston, K. Reynolds, and R. N. Sutton (May 1972). "Influenza infection causing manic psychosis". British Journal of Psychiatry 120 (558): 531–535. doi:10.1192/bjp.120.558.531. PMID 5041533. 
  50. ↑ Maurizi, C. P. (February 1985). "Influenza and mania: a possible connection with the locus ceruleus". Southern Medical Journal 78 (2): 207–209. PMID 3975719. 
  51. ↑ Keddie, K. M. (August 1965). "Toxic psychosis following mumps". British Journal of Psychiatry 111: 691–696. doi:10.1192/bjp.111.477.691. PMID 14337417. 
  52. ↑ Leweke FM, Koethe D (June 2008). "Cannabis and psychiatric disorders: it is not only addiction". Addict Biol 13 (2): 264–75. doi:10.1111/j.1369-1600.2008.00106.x. PMID 18482435. 
  53. ↑ THC and Psychosis from Neuropsychopharmacology 35, 764–774, dated 1 February 2010.
  54. ↑ Cannabis and Psychosis from the British Medical Journal, dated 8 July 2005.
  55. ↑ Degenhardt L (January 2003). "The link between cannabis use and psychosis: furthering the debate". Psychological Medicine 33 (1): 3–6. PMID 12537030. 
  56. ↑ Degenhardt L, Hall W, Lynskey M (2001) (PDF). Comorbidity between cannabis use and psychosis: Modelling some possible relationships.. Technical Report No. 121.. Sydney: National Drug and Alcohol Research Centre.. http://ndarc.med.unsw.edu.au/NDARCWeb.nsf/resources/TR_18/$file/TR.121.PDF. Retrieved 2006-08-19. 
  57. ↑ Lake CR, Masson EB, Quirk RS. (1988). "Psychiatric side effects attributed to phenylpropanolamine". Pharmacopsychiatry 21 (4): 171–81. doi:10.1055/s-2007-1014671. PMID 3060884. 
  58. ↑ Boyd, Alan (1995). "Bromocriptine and psychosis: A literature review". Psychiatric Quarterly 66 (1): 87–95. doi:10.1007/BF02238717. PMID 7701022. http://www.springerlink.com/content/y42v466374524k1m/. Retrieved 2008-09-06. 
  59. ↑ [1]
  60. ↑ Moore, M T; Nathan D, Elliot AR, Laubach C (1935). "Encephalographic studies in mental disease". American Journal of Psychiatry 92 (1): 43–67. 
  61. ↑ Copolov DL, Seal ML, Maruff P, et al. (April 2003). "Cortical activation associated with the experience of auditory hallucinations and perception of human speech in schizophrenia: a PET correlation study". Psychiatry Res 122 (3): 139–52. doi:10.1016/S0925-4927(02)00121-X. PMID 12694889. http://linkinghub.elsevier.com/retrieve/pii/S092549270200121X. 
  62. ↑ Pantelis, C; Velakoulis D, McGorry PD, Wood SJ, Suckling J, Phillips, LJ, Yung AR, Bullmore ET, Brewer W, Soulsby B, Desmond, P, McGuire PK (2003). "Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison". Lancet 25 (361 (9354)): 281–8. doi:10.1016/S0140-6736(03)12323-9. PMID 12559861. 
  63. ↑ Ho, BC; Alicata D, Ward J, Moser DJ, O'Leary DS, Arndt S, Andreasen NC (2003). "Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophrenia". American Journal of Psychiatry 160 (1): 142–8. doi:10.1176/appi.ajp.160.1.142. PMID 12505813. 
  64. ↑ Kapur S, Mizrahi R, Li M (November 2005). "From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosis". Schizophr. Res. 79 (1): 59–68. doi:10.1016/j.schres.2005.01.003. PMID 16005191. 
  65. ↑ Jones HM, Pilowsky LS (October 2002). "Dopamine and antipsychotic drug action revisited". Br J Psychiatry 181: 271–5. doi:10.1192/bjp.181.4.271. PMID 12356650. http://bjp.rcpsych.org/cgi/pmidlookup?view=long&pmid=12356650. 
  66. ↑ Soyka, Michael; Thomas Zetzsche, Stefan Dresel, and Klaus Tatsch (May 2000). "FDG-PET and IBZM-SPECT Suggest Reduced Thalamic Activity but No Dopaminergic Dysfunction in Chronic Alcohol Hallucinosis". Journal of Neuropsychiatry & Clinical Neurosciences 12 (2): 287–288. doi:10.1176/appi.neuropsych.12.2.287. PMID 11001615. 
  67. ↑ Zoldan, J.; G. Friedberg, M. Livneh, and E. Melamed. (July 1995). "Psychosis in advanced Parkinson's disease: treatment with ondansetron, a 5-HT3 receptor antagonist". Neurology 45 (7): 1305–1308. PMID 7617188. 
  68. ↑ Healy, David (2002). The Creation of Psychopharmacology. Cambridge: Harvard University Press. ISBN 0-674-00619-4. 
  69. ↑ Blakemore, SJ; Smith J, Steel R, Johnstone CE, Frith CD (2000). "The perception of self-produced sensory stimuli in patients with auditory hallucinations and passivity experiences: evidence for a breakdown in self-monitoring". Psychological Medicine 30 (5): 1131–9. doi:10.1017/S0033291799002676. PMID 12027049. 
  70. ↑ Lohr, JB; Caligiuri MP (1997). "Lateralized hemispheric dysfunction in the major psychotic disorders: historical perspectives and findings from a study of motor asymmetry in older patients". Schizophrophrenia Research 30 (27 (2-3)): 191–8. doi:10.1016/S0920-9964(97)00062-5. PMID 9416648. 
  71. ↑ Pizaagalli, D; Lehmann D, Gianotti L, Koenig T, Tanaka H, Wackermann J, Brugger P. (2000). "Brain electric correlates of strong belief in paranormal phenomena: intracerebral EEG source and regional Omega complexity analyses". Psychiatry Research 100 (3): 139–154. doi:10.1016/S0925-4927(00)00070-6. PMID 11120441. 
  72. ↑ Makarec, K; Persinger, MA (1985). "Temporal lobe signs: electroencephalographic validity and enhanced scores in special populations". Perceptual and Motor Skills 60 (3): 831–42. PMID 3927256. 
  73. ↑ Weinstein, S; Graves RE (2002). "Are creativity and schizotypy products of a right hemisphere bias?". Brain and Cognition 49 (1): 138–51. doi:10.1006/brcg.2001.1493. PMID 12027399. http://linkinghub.elsevier.com/retrieve/pii/S0278262601914939. Retrieved 2006-08-19. 
  74. ↑ Overall JE, Gorham DR. The Brief Psychiatric Rating Scale. Psychol Rep. 1962;10:799-812
  75. ↑ Kay, S.R., Fiszbien, A., & Opler, L.A. 1987. The Positive and Negetive Symptom Scale (PANNS) for schizophrenia. Schizophrenia Bulletin, 13, pp261-276
  76. ↑ Birchwood, M; Trower P (2006). "The future of cognitive-behavioural therapy for psychosis: not a quasi-neuroleptic". British Journal of Psychiatry 188: 108–108. doi:10.1192/bjp.bp.105.014985. PMID 16449695. 
  77. ↑ Haddock, G; Lewis S (2005). "Psychological interventions in early psychosis". Schizophrenia Bulletin 31 (3): 697–704. doi:10.1093/schbul/sbi029. PMID 16006594. 
  78. ↑ Nathans-Barel, I.; P. Feldman, B. Berger, I. Modai and H. Silver (2005). "Animal-assisted therapy ameliorates anhedonia in schizophrenia patients". Psychotherapy and Psychosomatics 74 (1): 31–35. doi:10.1159/000082024. PMID 15627854. 
  79. ↑ Birchwood, M; P. Todd, C. Jackson (1998). "Early Intervention in Psychosis: The Critical Period Hypothesis". British Journal of Psychiatry 172 (33): 53–59. 
  80. ↑ French, Paul; Anthony Morrison (2004). Early Detection and cognitive therapy for people at high risk of developing psychosis. Chichester: John Wiley and Sons. ISBN 0-470-86314-5. 
  81. ↑ Beer, M D (1995). "Psychosis: from mental disorder to disease concept". Hist Psychiatry 6 (22(II)): 177–200. doi:10.1177/0957154X9500602204. PMID 11639691. 
  82. ↑ Psychosis, Henry George Liddell, Robert Scott, A Greek-English Lexicon, at Perseus
  83. ↑ "Online Etymology Dictionary". Douglas Harper. 2001. http://www.etymonline.com/index.php?search=psychosis&searchmode=none. Retrieved 2006-08-19. 
  84. ↑ Berrios G E (1987). "Historical Aspects of Psychoses: 19th Century Issues". British Medical Bulletin 43 (3): 484–498. PMID 3322481. 
  85. ↑ Berrios G E, Beer D (1994). "The notion of Unitary Psychosis: a conceptual history". History of Psychiatry 5 (17 Pt 1): 13–36. doi:10.1177/0957154X9400501702. PMID 11639278. 

Further reading

  • Sims, A. (2002) Symptoms in the mind: An introduction to descriptive psychopathology (3rd edition). Edinburgh: Elsevier Science Ltd. ISBN 0-7020-2627-1

Personal accounts

External links

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